Just as Gru is getting used to his role as a family man and father to Margo, Edith and Agnes, an ultra-secret organization that fights evil on a global scale comes knocking. Now it's up to Gru, the Minions and Gru's new partner, Lucy, to find out who is responsible for a series of spectacular crimes. After all, it takes the world's greatest ex villain to catch the one vying to take his place.